No compromises on live cultures, for a healthier gut
Not only does it replenish probiotics, but it also promotes the growth of beneficial gut bacteria and inhibits potentially harmful bacteria, helping to alleviate issues such as bloating and irregular bowel movements, and restoring a light and comfortable feeling to your digestive system.
Active Ingredients
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Bacillus subtilis (HUS8)
Inhibits harmful bacteria; aids digestion and produces proteases; supports the intestinal barrier.
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Bacillus coagulans (SC-208)
Relieves intestinal discomfort; improves IBS and inflammatory bowel conditions; strongly activates the immune system.
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Bacillus licheniformis (SL-307)
Produces natural bacillocins (antibacterial); breaks down proteins; synthesizes B vitamins.
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Bacillus clausii (SC-109)
Antibiotic-resistant; a commonly used probiotic strain in clinical settings; balances the microbiota and reduces diarrhea.
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Bacillus indicus (HU36)
Boosts immunity; produces carotenoid antioxidants in the gut; promotes vitamin synthesis.
More Than Just Probiotics—Superior Benefits
Cutting-edge Spore Technology: Creating an Exceptional Experience
100% Spore Technology
Natural dormant structure that is resistant to stomach acid, bile, and antibiotics; requires no refrigeration and remains stable at room temperature for 5 years holobios.com.
Colonization & Repair: Rebuilding the Gut Microbiome
More than just “supplementation,” it reconstructs the gut microbiota structure, promoting the growth of beneficial bacteria and inhibiting harmful bacteria. Microbiome Labs
High Live Bacteria Count: 4 Billion CFU per serving
The highest live bacteria count among similar spore-based probiotics on the market; strain purity and activity are verified through laboratory sequencing for every batch.
Antioxidant + Nutritional Symbiosis
HU36 generates powerful antioxidants such as beta-carotene, lutein, lycopene, and astaxanthin within the gut, which are directly absorbed by the intestines.
Backed by Published Studies
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Science-Driven
A balance of biological innovation and rigorous scientific validation.
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Probiotic Pioneers
Originators of clinically validated, spore-based probiotics.
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Innovative Biotechnology
Evidence-based solutions that enhance care across diverse health categories.
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Microbiome Optimization
Committed to whole-body health through the balance and restoration of the gut microbiome.
Standard Lactobacillus/BifidobaceriumRESEED
Probiotics candie from stomach acid or heat exposure
Function bymultiplyingtheir ownstrain type
Can worsenbloating and gas in some individuals
Spore basedProbioticsRECONDITION
Encourage the growth of otherkeystone bacteria (like butyrate)for a flourishing microbiomeand the nutrients yourbody needs to thrive
Designed tomaintain efficacyand survivabilitythroughoutthe Gl tract
Instructions for Use
Week 1: 1 capsule every other day (with a meal)
Week 2: 1 capsule daily (with a meal)
Week 3 and beyond: 2 capsules daily (taken together with a meal) Microbiome Labs
Recommendation: Take continuously for 3–6 months to support a healthy gut microbiome.
Suitable for: Children aged 5 and older and adults
That’s why you should choose us
Clinically proven formula: Live bacteria reach the intestines directly—say goodbye to probiotics that “don’t work.”
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Regular probiotics | |
|---|---|---|
| Gentle and non-irritating | ||
| No refrigeration required | ||
| Live probiotics reach the intestines | ||
| Stomach-acid resistant and highly active |
Microbiome Labs MegaSporeBiotic Probiotics for Women & Men - Spore-Based Probiotic for Gut Health & Digestive Support - Shelf-Stable, Travel-Friendly, Mens & Womens Probiotics (60 Capsules)
Whole-spore probiotics that withstand stomach acid and bile, delivering live bacteria directly to the intestines.
The Most Frequently Asked Questions
Does it need to be refrigerated?
Does it need to be refrigerated?
No! Spore-forming probiotics are naturally stable and can be stored at room temperature away from light. They have a shelf life of up to 5 years and are convenient to take with you when you're on the go.
What is the live bacterial count?
What is the live bacterial count?
Each 2-capsule serving contains 4 billion CFU of a Bacillus complex. The spore form is extremely stable at room temperature, ensuring the live bacterial count is maintained without the need for refrigeration.
Can I take this while on antibiotics?
Can I take this while on antibiotics?
Yes, but we recommend waiting at least two hours after taking antibiotics. The spore structure helps reduce the damage antibiotics cause to the gut microbiota.
How long does it take to feel the effects?
How long does it take to feel the effects?
Most users notice an improvement in digestive comfort within 2–4 weeks. A 60-day clinical study showed that it effectively relieves abdominal discomfort and supports regular bowel movements.
What type of probiotic is MegaSporeBiotic?
What type of probiotic is MegaSporeBiotic?
It is a whole-spore probiotic blend made from natural spore-forming strains. Unlike conventional live-culture probiotics, it is resistant to stomach acid and bile and remains active even without refrigeration.
Is there clinical research supporting this strain?
Is there clinical research supporting this strain?
Yes, the formula has been validated by 10 peer-reviewed studies, which show that it enhances gut microbiota diversity, promotes the growth of beneficial bacteria, and reduces the number of potentially harmful bacteria.
Collapsible rowCan it help with constipation and diarrhea?
Collapsible rowCan it help with constipation and diarrhea?
Yes, it helps regulate the balance of gut flora, which improves bowel motility and relieves constipation, diarrhea, and bloating.
Will I experience bloating or increased flatulence after taking this?
Will I experience bloating or increased flatulence after taking this?
A small number of people may experience mild flatulence at first. This is a normal part of the gut flora adjustment process and usually resolves on its own within 1–3 days. There is no need to worry.
What is the main difference between this product and regular probiotics?
What is the main difference between this product and regular probiotics?
Most regular probiotics are inactivated by stomach acid and struggle to reach the intestines; however, its spore structure allows it to survive stomach acid and bile 100%, germinate, and colonize the intestines, resulting in greater efficacy.